https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11905 Wed 11 Apr 2018 10:56:58 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20339 Wed 11 Apr 2018 09:40:54 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13894 Wed 11 Apr 2018 09:40:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10028 Wed 11 Apr 2018 09:21:02 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12510 Sat 24 Mar 2018 08:18:42 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17373 Sat 24 Mar 2018 08:01:32 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:5537 T polymorphism located within the promoter region of the ΔDNMT3B gene has recently been reported to be associated with a significant increase to the risk of early onset CRC. In this study we determined the ΔDNMT3B genotype in 404 confirmed HNPCC participants (total of 194 CRC cases) from Australia (203) and Poland (201). Front the total number of participants there were 194 diagnosed cases of CRC and 210 healthy MMR gene Mutation carriers. The study was undertaken to assess whether the reported effect observed in a previous study of 146 HNPCC patients is consistent in a larger separate and unrelated participant cohort. Through the statistical tests of Kaplan-Meier survival analysis and Cox hazard regression models we did not observe any significant association between the ΔDNMT3B C>T SNP and early onset CRC in HNPCC patients.]]> Sat 24 Mar 2018 07:46:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:5385 Sat 24 Mar 2018 07:43:57 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32077 0.05). Global DNA methylation levels in males were significantly higher than in females (median %5-mC: 1.82 vs. 1.03, males and females respectively, (P < 0.05)). Conclusion: No association was found between the intake of one-carbon metabolism nutrients during the early postnatal period and global DNA methylation levels at age four years. Higher global DNA methylation levels in males warrants further investigation.]]> Mon 23 Sep 2019 11:18:49 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51568 Mon 11 Sep 2023 14:22:09 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40011 p > .05), though the estimates of effect were consistently negative. Global DNA methylation levels in males were significantly higher than in females (median %5mC: 1.82 vs. 1.03, males and females, respectively, (p < .05)). Conclusion: No association was found between global DNA methylation and child cognition and behavior; however given the small sample, this study should be pooled with other cohorts in future meta-analyses.]]> Fri 15 Jul 2022 10:09:55 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40367 Fri 08 Jul 2022 16:09:39 AEST ]]>